INFLAMMATION RESPONSE

INGREDIENTS:

Curcumin C3 Complex® (Turmeric)

What is Curcumin C3 Complex®?

• Curcumin C3 Complex® is an extract derived from the rhizomes (roots) of the plant Curcuma longa, also known as turmeric

• Curcumin C3 Complex® is the foremost clinically-­studied natural anti-­inflammatory and antioxidant with a variety of health benefits

·       Curcumin C3 Complex® is 95% curcuminoids: curcumin plus demethoxycurcumin and bisdemethoxycurcumin

o   The ratio of curcuminoids is detected by HPLC (high-performance liquid chromatography)

o   Curcumin is not less than 70% and not more than 80% w/w

o   Demethoxycurcumin is not less than 15% and not more than 25% w/w

o   Bisedemethoxycurcumin is not less than 2.5% and not more than 6.5% w/w

o   Studies of turmeric derivatives noted that the other two compounds are more efficient in protecting from oxidative stress than curcumin alone

o   Curcumin C3 Complex® is more soluble because of bisdemethoxycurcumin. Therefore, Curcumin C3 Complex® is more absorbable in the gastrointestinal tract and provides more health benefits than curcumin alone

Intense clinical studies have shown the health-supporting potentials of curcuminoids:

• Prevents tissue damage from free radicals (antioxidants)

• Anti-­inflammatory

• Boosts immunity

• Supports healthy cholesterol levels

• Supports healthy blood sugar levels

• Blocks platelet aggregation

• Protects liver from toxic compounds

• Stimulates macrophages to clear the central nervous system from Alzheimer’s disease-associated toxic oligomer

• Specifically inhibited virus replication in tested viruses

Some of these health-­supporting capacities are patented. The patents are available at https://www.curcuminoids.com/patents.htm
As a result of clinical trials, Curcumin C3 Complex® is claimed by MD Anderson Cancer Center in Houston, Texas, and UCLA as an ingredient of choice for cancer and Alzheimer’s disease treatment, respectively

BioPerine®:

What is BioPerine®?

• BioPerine® is a natural ingredient, which significantly improves the bioavailability and benefits of nutritive compounds, specifically Curcumin C3 Complex®.

• BioPerine® is a patented standardized extract from the fruits of Piper nigrum (black pepper)

• Piperine content in BioPerine® is much higher (95-¬99% pure piperine) than it is in black pepper; Piperine is only 3-¬9% in all parts of black pepper

How does piperine enhance the bioavailability of nutritive substances?

• Piperine interferes with substance-­converting enzymes, such as UDP-­glucuronyltransferase in the small intestine and liver. The excretion of the nutritional ingredients by the kidneys is blocked because the natural state of the nutritional ingredients is less soluble and their excretion through the urine is less efficient

• Vanilloid receptors are G protein coupled and highly expressed on afferent neurons of the gastrointestinal (GI) tract. Piperine binding to vanilloid receptors activates membrane‐bound adenyl cyclase, which catalyzes the synthesis of the second messenger molecule cAMP. cAMP activates protein kinase A (PKA) that inhibits intestinal motility and dilates blood vessels of the intestine. This physiological action may cause better digestion and absorption

• Piperine is likely to facilitate the absorption of nutrients interacting with the ultrastructure of intestinal brush border and stimulating digestive enzymes

BioPerine® has been shown to enhance the bioavailability of the following groups of nutrients in humans and animals:

• Resveratrol

• Herbal extracts (curcumin, ashwagandha, capsaicin, Gingko Biloba)

• Water soluble vitamins (vitamin B1, B2, B6, B12, niacinamide, folic acid and vitamin C)

• Fat-soluble vitamins (vitamins A, D, E, and K)

• Antioxidants (vitamin A, C, E, alpha-­‐carotene, trans beta­‐carotene, lycopene, lutein/zeaxanthin, pine bark bioflavonoids complex, germanium, selenium, and zinc)

• Amino acids (lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine and methionine)

• Minerals (calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper and magnesium)